Papel del zinc en
la endocrinología pediátrica


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Conclusión

Los cambios en el estado nutricional de zinc, sobre todo su deficiencia, afectan el sistema endocrino de varias maneras, y muchas hormonas influyen en la concentración corporal de este oligoelemento. Los diversos síntomas de deficiencia provienen principalmente del deterioro de las actividades de las enzimas y el trastorno funcional de las proteínas que contienen zinc

Los varios grados de deficiencia de zinc constituyen un problema mundial de salud pública, sobre todo en niños y mujeres embarazadas. Caulfield y colaboradores recopilaron considerable evidencia sobre el alto porcentaje de mujeres, en el mundo, que consumen dietas con cantidades inadecuadas de zinc Ellos estimaron grosso modo, que 82% de las mujeres embarazadas, en todo el mundo, ingieren dietas insuficientes en zinc como para satisfacer las necesidades normales del embarazo y en algunos países tal cifra es cercana a 100%.21 Aún en los países desarrollados, y más en las naciones en vías de desarrollo, prevalece la deficiencia marginal de zinc. Nosotros demostramos tal fenómeno en cerca de 60% de los niños japoneses con talla baja; la razón de tan alta frecuencia puede deberse principalmente al reciente predominio de comidas precocidas, pasabocas y comidas foráneas en sus dietas.24

Los nutricionistas y médicos, sobre todo pediatras y obstetras, deberían interesarse en el poder nutricional del zinc en niños y mujeres embarazadas, para prescribirles las dietas apropiadas con cantidades adecuadas de este oligoelemento.

Referencias

1. Thorlacius-Ussing O. Zinc in the anterior pituitary of rat: A histochemical and analytical work. Neuroendocrinology. 1987; 45: 233-42.

2. Cunningham BC, Mulkerrin MG, Wells JA. Dimerization of human growth hormone by zinc. Science. 1991; 253: 545-48.

3. Nishi Y. Zinc and growth. J Am Coll Nutr. 1996; 15: 340-4.

4. Aihara K, Nishi Y, Hatano S, et al. Zinc, copper, manganese, and selenium metabolism in patients with human growth hormone deficiency or acromegaly. J Pediatr Gastroenterol Nutr 1985; 4: 610-15.

5. Kaji M, Miki A, Sakai T, Wariishi M. Effects of growth hormone replacement therapy on the hair trace metal concentrations. Biomed Res Trace Elements. 1998; 9: 167-8.

6. Prasad AS, Miale A, Farid Z, et al. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism. J Lab Clin Med. 1963; 61: 537-49.

7. Prasad AS. Zinc deficiency in women, infants and children. J Am Coll Nutr. 1996; 15: 113-20.

8. Hambidge KM, Hambidge C, et al. Low levels of zinc in hair, anorexia, poor growth, and hypogeusia in children. Pediatr Res. 1972; 6: 868-74.

9. Slonim AE, Sadick N, et al. Clinical response of alopecia, trichorrhexis nodosa, and dry, scaly skin to zinc supplementation. J Pediatr. 1992; 121: 890-5.

10. Favier AE. Hormonal effects of zinc on growth in children. Biol Trace Elem Res. 1992; 32: 383-98.

11. Nishi Y, Hatano S, Aihara K, Fujie A, Kihara M. Transient partial growth hormone deficiency due to zinc deficiency. J Am Coll Nutr. 1989; 8: 93-7.

12. Kirksey A, Wachs TD, Yunis F, et al. Relation of maternal zinc nutriture to pregnancy outcome and infant development in an Egyptian village. Am J Clin Nutr. 1994; 60: 782-92.

13. Neggers YH, Cutter GR, Acton RT, et al. A positive association between maternal serum zinc concentration and birth weight. Am J Clin Nutr. 1990; 51: 678-84.

14. Ghosh A, Fong LYY, Wan CW, Liang ST, Woo JSK, Wong V. Zinc deficiency is not a cause for abortion, congenital abnormality and small-for-gestational age infant in Chinese women. Br J Obstet Gynaecol. 1985; 92: 886-91.

15. Tamura T, Goldenberg RL, Johnston KE, DuBard M. Maternal plasma zinc concentrations and pregnancy outcome. Am J Clin Nutr. 2000; 71: 109-13.

16. Nakamura T, Nishiyama S, Futagoishi-Suginohara Y, Matsuda I, Higashi A. Mild to moderate zinc deficiency in short children: Effect of zinc supplementation on linear growth velocity. J Pediatr. 1993; 123: 65-9.

17. Mahomed K, James DK, Golding J, McCabe R. Zinc supplementation during pregnancy: a double blind randomized controlled trial. Brit Med J. 1989; 299: 826-30.

18. Simmer K, Lort-Phillips L, James C, Thompson RPH. A doubleblind trial of zinc supplementation in pregnancy. Eur J Clin Nutr. 1991; 45: 139-44.

19. Goldenberg RL, Tamura T, Neggers Y, et al. The effect of zinc supplementation on pregnancy outcome. JAMA. 1995; 274: 463-8.

20. Osendarp SJM, van Raaij JMA, et al. A randomized, placebo-controlled trial of the effect of zinc supplementation during pregnancy on pregnancy outcome in Bangladeshi urban poor. Am J Clin Nutr. 2000; 71: 114-9.

21. Caulfield LE, Zavaleta N, Shankar AH, Merialdi M. Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival. Am J Clin Nutr. 1998; 68(suppl): 499S-508S.

22. Michaelsen KF, Samuelson G, Graham TW, Lonnerdal B. Zinc intake, zinc status and growth in a longitudinal study of healthy Danish infants. Acta Paediatr. 1994; 83: 1115-21.

23. Prentice A. Does mild zinc deficiency contribute to poor growth performance? Nutr Rev. 1993; 51: 268-70.

24. Kaji M, Gotoh M, Takagi Y, Masuda H, Kimura Y, Uenoyama Y. Studies to determine the usefulness of the zinc clearance test to diagnose marginal zinc deficiency and the effects of oral zinc supplementation for short children. J Am Coll Nutr. 1998; 17: 388-91.

25. Castillo-Duran C, García H, Venegas P, et al. Zinc supplementation increases growth velocity of male children and adolescents with short stature. Acta Paediatr. 1994; 83: 833-7.

26. Ninh NX, Thissen JP, Maiter D, Adam E, Mulumba N, Ketelslegers JM. Reduced liver insulin-like growth factor-I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (HC) receptors and serum Hcbinding protein. J Endocrinol. 1995; 144: 449-56.

27. Yamaguchi M. Role of zinc in bone formation and bone resorption. J Trace Elem Exper Med. 1998; 11: 119-35.

28. Yamaguchi M, Inamoto K. Differential effects of calcium-regulating hormones on bone metabolism in weanling rats orally administered zinc sulfate. Metabolism. 1986; 35: 1044-7.

29. McDonnell DP, Mongelsdorf DJ, Pike JW, Haussler MR, O’Malley BW. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science. 1987; 235: 1214-7.

30. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993; 73: 79-118.

31. Kvist U, Bjorndahl L. Zinc preserves an inherent capacity for human sperm chromatin decondensation. Acta Physiol Scand. 1985; 124: 195-200.

32. Kvist U, Kjellberg S, Bjorndahl L, Hammar M, Roomans GM. Zinc in sperm chromatin and chromatin stability in fertile men and men in barren unions. Scand J Urol Nephrol. 1988; 22: 1-6.

33. Bjorndahl L, Kvist U. Importance of zinc for human sperm headtail connection. Acta Physiol Scand. 1982; 116: 51-5.

34. Huret JL. Nuclear chromatin decondensation of human sperm: a review. Arch Androl. 1986; 16: 97-109.

35. Nishi Y, Hatano S, Aihara K, et al. Effect of zinc ion on human chorionic gonadotropin-stimulated in vitro production of cyclic AMP and testosterone by rat testis. Pediatr Res. 1984; 18: 232-5.

36. McClain CJ, Gavaler JS, Van-Thiel DH. Hypogon adism in the zinc-deficient rat: localization of the functional abnormalities. J Lab Clin Med. 1984; 104: 1007-15.

37. Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med. 1980; 96: 544-50.

38. Hunt CD, Johnson PE, Herbel J, Mullen LK. Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men. Am J Clin Nutr. 1992; 56: 148-57.

39. Vallejo M, Lightman SL. Basic principles. In: Grossman A, ed. Clinical Endocrinology, 2nd ed. Oxford, England: Blackwell Science Ltd: 1998; 3-24.

40. Ronaghy HA, Halsted JA. Zinc deficiency occurring in females. Report of two cases. Am J Clin Nutr. 1975; 28: 831-6.

41. Favier AE. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res. 1992; 32: 363-82.

42. Brandao-Neto J, de Mendonca BB, Shuhama T, et al. Zinc: An inhibitor of prolactin (PRL) secretion in humans. Horm Metab Res. 1989; 21: 203-6.

43. Aihara K, Nishi Y, Hatano S, et al. Zinc, copper, manganese, and selenium metabolism in thyroid disease. Am J Clin Nutr. 1984; 40: 26-35.

44. Dolev E, Deuster PA, Solomon B, Trostmann UH, Wartofsky L, Burman KD. Alterations in magnesium and zinc metabolism in thyroid disease. Metabolism. 1988; 37: 61-7.

45. Yoshida K, Kiso Y, Watanabe T, et al. Erythrocyte zinc in hyperthyroidism: reflection of integrated thyroid hormone levels over the previous few months. Metabolism. 1990; 39: 182-6.

46. Kralik A, Eder K, Kirchgessner M. Influence of zinc and selenium deficiency on parameters relating to thyroid hormone metabolism. Horm Metab Res. 1996; 28: 223-6.

47. Wada L, King JC. Effect of low zinc intakes on basal metabolic rate, thyroid hormones and protein utilization in adult men. J Nutr. 1986; 116: 1045-53.

48. Arreola F, Paniagua R, Perez A, et al. Effect of zinc treatment on serum thyroid hormones in uremic patients under peritoneal dialysis. Horm Metab Res. 1993; 25: 539-42.

49. Nishiyama S, Futagoishi-Suginohara Y, Matsukura M, et al. Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency. J Am Coll Nutr. 1994;13: 62-7.

50. Fabris N, Mocchegiani E, Amadio L, Zannotti M, Licastro F, Franceschi C. Thymic hormone deficiency in normal ageing and Down’s syndrome: is there a primary failure of the thymus? Lancet. 1984; i: 983-6.

51. Napolitano G, Palka G, Lio S, et al. Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome? Ann Genet. 1990; 33: 9-15.

52. Licastro F, Mocchegiani E, Zannotti M, Arena G, Masi M, Fabris N. Zinc affects the metabolism of thyroid hormones in children with Down’s syndrome: Normalization of thyroid stimulating hormone and of reversal triiodothyronine plasmic levels by dietary zinc supplementatio. Intern J Neuroscience. 1992; 65: 259-68.

53. Bucci I, Napolitano G, Giuliani C, et al. Zinc sulfate supplementation improves thyroid function in hypozincemic Down children. Biol Trace Elem Res. 1999; 67: 257-68.

54. Nishiyama S, Nakamura T, Higashi A, Matsuda I. Infusion of zinc inhibits serum calcitonin levels in patients with various zinc status. Calcif Tissue Int. 1991; 49: 179-82.

55. Walter RM, Uriu-Hare JY, Olin KL, et al. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care. 1991; 14: 1050-6.

56. Cunningham JJ, Fu A, Mearkle PL, Brown RG. Hyperzincuria in individuals with insulin-dependent diabetes mellitus: Concurrent zinc status and the effect of high-dose zinc supplementation. Metabolism. 1994; 43: 1558-62.

57. Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr. 1998; 17: 109-15.

58. El-Yazigi A, Hannan N, Raines DA. Effect of diabetic state and related disorders on the urinary excretion of magnesium and zinc in patients. Diabetes Res. 1993; 22: 67-75.

59. Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C, Malarkey W. Short-term zinc supplementation in women with non-insulindependent deabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro. Am J Clin Nutr. 1997; 66: 639-42.

60. Boqvist L, Lernmark A. Effects on the endocrine pancreas in Chinese hamsters fed zinc deficient diets. Acta Pathol Microbiol Scand. 1969; 76: 215-8.

61. Haglund B, Ryckenberg K, Selinus O, Dahlquist G. Evidence of a relationship between childhood-onset type I diabetes and low groundwater concentration of zinc. Diabetes Care. 1996; 19: 873-5.

62. Sumoski W, Baquerizo H, Rabinovitch A. Oxygen free radical scavengers protect rat islet cells from damage by cytokines. Diabetologia. 1989; 32: 792-6.

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